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Document 2361
DOCN M94A2361
TI Mortality in HIV infection in Switzerland and U.S.A. Swiss HIV Cohort
Study (SHCS) and Community Programs for Clinical Research on AIDS
(CPCRA).
DT 9412
AU Egger M; Wentworth D; von Overbeck J; Sherer R; Ledergerber B;
Saravolatz L
SO Int Conf AIDS. 1994 Aug 7-12;10(1):321 (abstract no. PC0215). Unique
Identifier : AIDSLINE ICA10/94370214
AB OBJECTIVE: To compare mortality of patients with HIV infection enrolled
in cohort studies in Switzerland and the US. Patients and setting: The
SHCS and the CPCRA are cohort studies of adult HIV-infected patients
with 6 and 17 recruiting centers respectively. Both studies used similar
standardised methods for data collection and follow-up. METHODS:
Analyses are restricted to patients with a baseline CD4+ cell count
within 90 days of enrollment. Cumulative mortality is estimated using
the Kaplan-Meier method. RESULTS: 4,965 Swiss and 4,547 US patients
enrolled between 1/88 and 7/93 and 9/90 and 9/93 respectively were
considered. Compared to US participants, Swiss participants were younger
(33 vs. 38 years), more likely to be female (27% vs. 17%) and injecting
drug users (44% vs. 30%). Median CD4+ cell counts at entry were 324 and
150. Nearly all Swiss participants were white, whereas 52% of US
participants were non-white. Kaplan-Meier lifetable estimates stratified
by CD4+ cell counts were: TABULAR DATA, SEE ABSTRACT VOLUME.
CONCLUSIONS: Despite important differences at baseline, the mortality of
Swiss and US cohort participants overall appears to be similar when
stratified on CD 4 cell counts at entry. Detailed comparisons across
different cohorts may identify factors associated with disease
progression and mortality.
DE Adult Cohort Studies Comparative Study Female Human HIV
Infections/IMMUNOLOGY/*MORTALITY Leukocyte Count Male
Switzerland/EPIDEMIOLOGY T4 Lymphocytes United States/EPIDEMIOLOGY
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).